Most RTKs are single subunit receptors but some exist as multimeric complexes, e.g., the insulin receptor that forms disulfide linked dimers in the presence of hormone (insulin) moreover, ligand binding to the extracellular domain induces formation of receptor dimers.
RTK class XVIII ( MuSK receptor family). RTK class II ( Insulin receptor family). RTK class I ( EGF receptor family) (ErbB family). Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains. Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. 
Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins.
Receptor tyrosine kinases ( RTKs) are the high- affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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